
For some as yet unknown reason, supercentenarians are resistant to diseases such as Alzheimer's, heart disease and cancer. In an effort to emulate this apparent medical miracle, scientists successfully reprogrammed cells from a 114-year-old woman, the first time such a feat had been managed in history.
“Why do supercentenarians age so slowly?” says study author Evan Y. Snyder. “We are now set to answer that question in a way no one has been able to before.”
The team of scientists from Sanford Burnham Prebys and private company AgeX Therapeutics reprogrammed blood cells from a 114-year-old woman, a 43-year-old individual and an 8-year-old child with progeria, a condition which causes rapid aging, in order to unravel the mystery mechanics behind the aging process.
In their study, Snyder's team first created a general purpose kind of stem cell known as pluripotent stem cells (iPSCs) from the blood cells before transforming them into a more specific kind of stem cell known as mesenchymal stem cells, which help maintain our bodies' structural tissues like bone, cartilage and fat. Much to their pleasant surprise, the researchers found that all three participants' cells transformed as easily as each other.
However, the researchers admit that telomere resets occurred less frequently among the supercentenarian cells than the others.
The pharmaceutical industry could then concentrate on developing drugs to thwart these particular processes or mimic the patterns exhibited by the supercentenarian cells.
Source: rt.com
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